{"id":1656,"date":"2025-06-13T16:15:06","date_gmt":"2025-06-13T12:15:06","guid":{"rendered":"https:\/\/pedaqoq.az\/?p=1656"},"modified":"2025-06-13T16:15:07","modified_gmt":"2025-06-13T12:15:07","slug":"botaniklerin-hemmuellifi-oldugu-meqale-steroids-jurnalinda-cap-olunub","status":"publish","type":"post","link":"https:\/\/pedaqoq.az\/?p=1656","title":{"rendered":"BOTAN\u0130KL\u018fR\u0130N H\u018fMM\u00dc\u018fLL\u0130F\u0130 OLDU\u011eU M\u018fQAL\u018f STEROIDS JURNALINDA \u00c7AP OLUNUB"},"content":{"rendered":"\n

AR ETN Botanika \u0130nstitutu v\u0259 Pakistan\u0131n Kara\u00e7i \u015f\u0259h\u0259rind\u0259n Dr. Panjwani Molekulyar Tibb v\u0259 D\u0259rman T\u0259dqiqatlar\u0131 M\u0259rk\u0259zi, H.E.J. T\u0259dqiqat Kimya \u0130nstitutu, Beyn\u0259lxalq Kimya v\u0259 Biologiya Elml\u0259ri M\u0259rk\u0259zi v\u0259 Lahor \u015f\u0259h\u0259rind\u0259n Molekulyar Biologiya v\u0259 Biokimya \u0130nstitutunun \u0259m\u0259kda\u015flar\u0131n\u0131n (Yusifova Y., tul-Wahab A., Choudhary M.I., Siddiqui M., Khan N., Atif M., Zafar H., Ibadullayeva S.I., Aghayeva D.N.) birg\u0259 s\u0259yi n\u0259tic\u0259sind\u0259 Az\u0259rbaycanda me\u015f\u0259 a\u011faclar\u0131nda bit\u0259n Laetiporus sulphureus (Bull.) Murrill g\u00f6b\u0259l\u0259k kulturalar\u0131ndan \u0259ld\u0259 edil\u0259n ikinci metabolitl\u0259r v\u0259 onlar\u0131n d\u00f6\u015f x\u0259r\u00e7\u0259ngi d\u0259rman\u0131 eksemestan\u0131n\u0131n biotransformasiyas\u0131 \u00fc\u00e7\u00fcn katalizator kimi istifad\u0259 imkanlar\u0131 \u00f6yr\u0259nilmi\u015f v\u0259 n\u0259tic\u0259l\u0259r istinad \u0259msal\u0131 4.3 v\u0259 \u0130mpact faktoru 2.4 olan \u201cSTEROIDS\u201d jurnal\u0131nda d\u0259rc olunmu\u015fdur. M\u0259lumdur ki, haz\u0131rda b\u0259zi g\u00f6b\u0259l\u0259kl\u0259r dad\u0131na v\u0259 m\u00fcxt\u0259lif vacib vitaminl\u0259rin, minerallar\u0131n v\u0259 ikincil metabolitl\u0259rin m\u00f6vcudlu\u011funa g\u00f6r\u0259 a\u015fa\u011f\u0131 kalorili qida \u0259lav\u0259l\u0259ri kimi istifad\u0259 olunur. Eyni zamanda onlar\u0131n b\u0259zil\u0259ri m\u00fcalic\u0259vi \u0259h\u0259miyy\u0259t\u0259 malikdir v\u0259 \u0259n\u0259n\u0259vi tibbd\u0259 istifad\u0259 olunur.<\/p>\n\n\n\n

M\u0259qal\u0259d\u0259 \u0259ks olunan t\u0259dqiqat i\u015find\u0259 g\u00f6b\u0259l\u0259k h\u00fcceyr\u0259l\u0259ri \u00fczvi birl\u0259\u015fm\u0259l\u0259rin t\u00f6r\u0259m\u0259l\u0259rinin al\u0131nmas\u0131 \u00fc\u00e7\u00fcn biokatalizator kimi istifad\u0259 edilmi\u015f v\u0259 n\u0259tic\u0259 olaraq (1) L. sulphureus g\u00f6b\u0259l\u0259yind\u0259n 3\u03b2-hidroksi-24-metilenelanost-8-en-21-oik tur\u015fusu ayr\u0131lm\u0131\u015f, (2) g\u00f6b\u0259l\u0259yin h\u00fcceyr\u0259 kulturas\u0131 d\u00f6\u015f x\u0259r\u00e7\u0259ngi d\u0259rman\u0131 olan eksemestan\u0131n yeni metabolit\u0259 biotransformasiyas\u0131 \u00fc\u00e7\u00fcn istifad\u0259 edilmi\u015f v\u0259 bel\u0259likl\u0259 (3)18-hidroksi-6-metilen-androsta1,4-dien-3,17-dion yeni metaboliti \u0259ld\u0259 edilmi\u015fdir.<\/p>\n\n\n\n

T\u0259dqiqat i\u015find\u0259 iki madd\u0259 m\u00fcxt\u0259lif xromatoqrafik \u00fcsullardan istifad\u0259 edil\u0259r\u0259k t\u0259mizl\u0259nmi\u015f, 1D- v\u0259 2D-NMR, HREI-MS v\u0259 IR-spektroskopik \u00fcsullar\u0131n k\u00f6m\u0259yi il\u0259 strukturlar\u0131 m\u00fc\u0259yy\u0259n edilmi\u015fdir. Madd\u0259 1 steroidal skelet\u0259 malik olub yeni \u00e7evrilm\u0259 il\u0259 al\u0131nan dig\u0259r m\u0259hsulu (aromataz\u0131) inhib\u0259 etm\u0259 potensial\u0131na g\u00f6r\u0259 qiym\u0259tl\u0259ndirilmi\u015fdir. Aromataz estrogen biosintezind\u0259 m\u00fch\u00fcm rol oynay\u0131r ki, bu da onun inhib\u0259sini estrogen reseptor-pozitiv (ER+) d\u00f6\u015f x\u0259r\u00e7\u0259nginin m\u00fcalic\u0259si \u00fc\u00e7\u00fcn \u0259sas terapevtik strategiyaya \u00e7evirir.<\/p>\n

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AR ETN Botanika \u0130nstitutu v\u0259 Pakistan\u0131n Kara\u00e7i \u015f\u0259h\u0259rind\u0259n Dr. Panjwani Molekulyar Tibb v\u0259 D\u0259rman T\u0259dqiqatlar\u0131<\/p>\n","protected":false},"author":2,"featured_media":1657,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":["post-1656","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uni"],"_links":{"self":[{"href":"https:\/\/pedaqoq.az\/index.php?rest_route=\/wp\/v2\/posts\/1656","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pedaqoq.az\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pedaqoq.az\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pedaqoq.az\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pedaqoq.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1656"}],"version-history":[{"count":1,"href":"https:\/\/pedaqoq.az\/index.php?rest_route=\/wp\/v2\/posts\/1656\/revisions"}],"predecessor-version":[{"id":1658,"href":"https:\/\/pedaqoq.az\/index.php?rest_route=\/wp\/v2\/posts\/1656\/revisions\/1658"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pedaqoq.az\/index.php?rest_route=\/wp\/v2\/media\/1657"}],"wp:attachment":[{"href":"https:\/\/pedaqoq.az\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1656"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pedaqoq.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1656"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pedaqoq.az\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1656"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}